Tranexamic Acid's Role in the Prevention of Hyperpigmentation
In 1979, it was discovered quite by accident that tranexamic acid reduced the intensity of melasma. Tranexamic acid is an amino acid, and has been used in the treatment of physical trauma and to prevent the breakdown of fibrin, which is a cross-linked protein that closes wounds. But after it was orally administered, it was observed that it reduced the appearance of melasma over the course of 2-3 weeks.
Melasmas are areas of hyperpigmentation that are triggered by a variety of influences, like UV light exposure, hormonal fluctuations, inflammation, advanced glycation endproducts, or photosensitization. They can be particularly difficult to effect, and can cause considerable distress for a client.
Combining niacinamide, or Vitamine B3, with tranexamic acid (as in dermaviduals Complexion Skin Care Liposome Plus) produces a synergistic effect: the tranexamic acid inhibits tyrosinase and the B3 interferes with the melanosomes transport function, and when transported in a liposomal format, the phosphatidylcholine aids penetration. It can also reduce the appearance of superficial blood vessels and provide an even skin tone. These same benefits also make this power duo an excellent choice for the treatment of rosacea, and when combined with azelaic acid (found in Liposome Concentrate Plus) or boswellic acid (Boswellia Nanoparticles) they make a highly effect treatment for acne.
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